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Advanced Science, part of the prestigious Wiley Advanced portfolio, is an open access interdisciplinary science journal publishing the best-in-class fundamental and applied research in materials science, physics, chemistry, medical and life sciences, and engineering. Our mission is to give top science the maximum accessibility through open access publishing.
The Advanced portfolio from Wiley is a family of globally respected, high-impact journals that disseminates the best science from well-established and emerging researchers so they can fulfill their mission and maximize the reach of their scientific discoveries.
On the Cover
Articles
Superior High‐Rate Ni‐Rich Lithium Batteries Based on Fast Ion‐Desolvation and Stable Solid‐Electrolyte Interphase
-  7 February 2025
Graphical Abstract

A customized electrolyte for coordinating ion desolvation and interphase formation of superior high-rate Ni-rich lithium batteries is developed. A stable double-layered CEI is generated, and a -dominated solvation structure is induced to effectively decrease the desolvation energy, both of which support fast lithium ion transport in the cathode interfacial processes.
Loss of MNX1 Sensitizes Tumors to Cytotoxic T Cells by Degradation of PD‐L1 mRNA
-  6 February 2025
Graphical Abstract

This study presents motor neuron and pancreas homeobox 1 (MNX1)-mediated programmed cell death ligand-1 (PD-L1) mRNA stability in cancer cells as a novel immunosuppressive mechanism. MNX1, stabilized by MNX1-AS1, binds to YBX1 to enhance PD-L1 mRNA stability. Loss of MNX1 enhances T cell anti-tumor immunity and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blockade therapy, providing a potential strategy for cancer immunotherapy.
Immunometabolism of Liver Xenotransplantation and Prospective Solutions
-  6 February 2025
Graphical Abstract

After xenotransplantation, pig livers will replace those of human patients to maintain the stability of metabolism and immune system. The incompatibility of immunometabolism between humans and pigs induces rejection, inflammation, coagulation dysfunction, and liver failure. The profile of immunometabolism pre-transplantation and post-transplantation is meaningful for the establishment of donor pigs and the achievement of immune tolerance. Adapted with permission from BioRender. Kelai, W. (2024).
Highly Efficient Electrocatalytic Uranium Extraction from Seawater over an Amidoxime‐Functionalized In–N–C Catalyst
-  17 June 2022
Graphical Abstract

Porous indium−nitrogen−carbon capsules functionalized with flexible amidoxime groups enable highly efficient uranium extraction from seawater. The flexible amidoxime groups allow selective uranyl adsorption, while the InNx single atom sites provide a reversible single electron transfer platform for uranyl conversion to a harvestable Na2O(UO3·H2O)x precipitate via a U(V) intermediate.
“N-π-N” Type Oligomeric Acceptor Achieves an OPV Efficiency of 18.19% with Low Energy Loss and Excellent Stability
-  16 June 2022
Graphical Abstract

A novel oligomeric acceptor 2BTP-2F-T, constructed by linking two non-fullerene acceptors with thiophene, is reported. It exhibits superior characteristics over its monomer and polymer, including higher absorption coefficient and electron mobility in pristine materials, and welltuned morphology in PM6 blends, pushing an attain of efficiency of 18.19% with improved fill factor and short circuit current under similar energy loss.
Polypyrrole Nanoenzymes as Tumor Microenvironment Modulators to Reprogram Macrophage and Potentiate Immunotherapy
-  9 June 2022
Graphical Abstract

Second near-infrared light-activated Cu-doped polypyrrole nanozyme (CuP) with hyperthermia-enhanced trienzyme-like activities, including CAT, POD, and GPx, are elaborately synthesized via a straightforward one-step procedure for causing irreversible oxidative stress damage to tumor cells and reversing immunosuppressive tumor microenvironment by re-educating macrophage from pro-tumoral M2 to anti-tumoral M1 phenotype.